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KMID : 0359720170350040211
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Journal of the Korean Neurological Association
2017 Volume.35 No. 4 p.211 ~ p.214
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Co-occurrence of Guillain-Barre Syndrome and Acute Disseminated Encephalomyelitis with Dual Positive of Anti-GT1a and Anti-GM1 Antibodies
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Lee Ju-Young
Yoo Jin-Hyuk
Kang Dong-Gook
Kim Ye-Rim
Yoon Byeol-A
Kim Jong-Kuk
Bae Jong-Seok
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Abstract
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Acute disseminated encephalomyelitis (ADEM) and Guillain-Barre syndrome (GBS) are both rare post-infectious neurological disorders. The co-existence of these conditions has often been reported despite of low incidence. We describe a 20-year-old male, who presented with acute flaccid paralysis and encephalopathy. The patient showed reversible MRI lesions suggesting ADEM. This case showed anti-GT1a IgG and anti-GM1 IgM antibodies positivity. We suggest that certain immunogenicity within central and peripheral nervous system may share a common autoimmune process during the disease course.
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KEYWORD
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Acute disseminated encephalomyelitis, Guillain-Barre syndrome, Gangliosides
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